𝔖 Bobbio Scriptorium
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Inhibition of cellular iron uptake by haem in mouse erythroleukaemia cells

✍ Scribed by Antonin Hradilek; Jan Neuwirt

Book ID
114711943
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
540 KB
Volume
73
Category
Article
ISSN
0007-1048

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX