The effect of metabolic inhibitors on nontransferrin bound iron transport by K562 cells was investigated. Incubation with 1 microM rotenone, 10 microM antimycin, or 0.5 mM 2,4-dinitrophenol effectively reduced ATP levels by approximately 50%. Both the rate and extent of Fe+3 uptake were impaired in
Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron
โ Scribed by D Trinder; E Morgan
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 279 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0270-9139
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๐ SIMILAR VOLUMES
HFE-related hereditary hemochromatosis results in hepatic iron overload. Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by th
## The hepatic uptake of transferrin-bound iron by a Iron is required for the synthesis of many heme and nontransferrin receptor (NTR)-mediated process was non-heme proteins and enzymes necessary for cellular investigated using the human hepatoma cell line HuH7. growth and metabolism. Most cells t