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Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron

โœ Scribed by D Trinder; E Morgan


Book ID
118686670
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
281 KB
Volume
26
Category
Article
ISSN
0270-9139

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The effect of metabolic inhibitors on nontransferrin bound iron transport by K562 cells was investigated. Incubation with 1 microM rotenone, 10 microM antimycin, or 0.5 mM 2,4-dinitrophenol effectively reduced ATP levels by approximately 50%. Both the rate and extent of Fe+3 uptake were impaired in