Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane
β Scribed by K. Singletary; C. MacDonald
- Book ID
- 117466516
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 274 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0304-3835
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## Abstract We demonstrate in cell culture that mammary epithelial cells from normal human breast specimens metabolize benzo(a)pyrene (BaP) and form adducts with the bases of their DNA more readily and at lower concentrations of BaP than do fibroblasts from the same specimens. BaP metabolism and ad
## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyreneβDNA (BPβDNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 ΞΌM BP for 24 hr in the presence or absence of 5 ΞΌM CHLN, we measured BPβDNA adducts by chemiluminescence immunoassay (C