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Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells

✍ Scribed by Keith W. Singletary; Sean L. Barnes; Richard B. van Breemen


Book ID
116332896
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
185 KB
Volume
203
Category
Article
ISSN
0304-3835

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 ΞΌM BP for 24 hr in the presence or absence of 5 ΞΌM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C