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Induction of CYP1A1 and CYP1B1 and formation of carcinogen–DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene

✍ Scribed by Channa Keshava; Rao L. Divi; Diana L. Whipkey; Bonnie L. Frye; Erin McCanlies; Maryanne Kuo; Miriam C. Poirier; Ainsley Weston


Book ID
116333345
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
263 KB
Volume
221
Category
Article
ISSN
0304-3835

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## Abstract We hypothesized that chlorophyllin (CHLN) would reduce benzo[__a__]pyrene‐DNA (BP‐DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 μM BP for 24 hr in the presence or absence of 5 μM CHLN, we measured BP‐DNA adducts by chemiluminescence immunoassay (C