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Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa

✍ Scribed by Angela C. Chi; Kathryn Appleton; Joel B. Henriod; Joe W. Krayer; Nicole M. Marlow; Dipankar Bandyopadhyay; Ryan C. Sigmon; David T. Kurtz


Book ID
113833210
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
340 KB
Volume
45
Category
Article
ISSN
1368-8375

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## Abstract In the rat, expression of the __CYP1A1__ gene is closely associated with arylhydrocarbon hydroxylase (AHH) enzyme activity. AHH is an inducible enzyme activity known to play an important role in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic and carcinogenic m