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Omeprazole Alleviates Benzo[a]pyrene Cytotoxicity by Inhibition of CYP1A1 Activity in Human and Mouse Hepatoma Cells

โœ Scribed by Kazuhiro Shiizaki; Seiichiroh Ohsako; Masanobu Kawanishi; Takashi Yagi

Book ID
111316565
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
377 KB
Volume
103
Category
Article
ISSN
1742-7835

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## Abstract In the rat, expression of the __CYP1A1__ gene is closely associated with arylhydrocarbon hydroxylase (AHH) enzyme activity. AHH is an inducible enzyme activity known to play an important role in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic and carcinogenic m