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Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: Roles of PAH interactions and PAH metabolites

✍ Scribed by David C. Spink; Susan J. Wu; Barbara C. Spink; Mirza M. Hussain; Dilip D. Vakharia; Brian T. Pentecost; Laurence S. Kaminsky


Book ID
113924206
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
863 KB
Volume
226
Category
Article
ISSN
0041-008X

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## Abstract The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl‐inositol‐3 (PI‐3) kinases su