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Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615

✍ Scribed by Denise G. Redkar-Brown; David Aharony

Book ID
115882796
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
772 KB
Volume
165
Category
Article
ISSN
0014-2999

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro