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Inhibition of leukotriene-induced contraction of guinea pig trachea by 5-lipoxygenase inhibitors

โœ Scribed by Susan F. Schwalm; Alan J. Lewis; James M. Hand


Book ID
119050658
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
349 KB
Volume
33
Category
Article
ISSN
0090-6980

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro