Inhibition by streptovaricins of rauscher leukemia virus splenomegaly

✍ Scribed by Ernest C. Borden; William A. Carter; Lyle L. Sensenbrenner; Albert H. Owens; Judith Lichtenstein; Gary D. Gray; Gary L. Neil; F. Richard Nichol; L. H. Li

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: French
• Weight: 560 KB
• Volume: 14
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910140616

✦ Synopsis

Abstract

Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25‐50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv wus measurable in plasma. For up to 6h. SvC, at 300 mglkglday, reduced mean splecln weight of infected mice, from 478±51 (SE) mg to 300555 (SE) mg. Rijampicin, at 250 mglkglday, had no similar activity. Decrease in caloric intake and in body‐weight gain also resulted in an inhibition of RL V splenomegaly; although Sv‐treated mice gained weight, the increase was usually slightly less than controls. However, mice treated with a Sv diet for a week prior to infection, after an initial period of weight loss, gained at a rate equivalent to a controlgroup, and when killed had a marked reduction in splenomegaly. The selectivity of streptovaricins and specificity for viral events was suggested by several observations: (I) Splenomegaly and mortality, induced by L1210 or a non‐injective transplantable tumor of RL V oriAjin, was not inhibited. (2) No inhibition of normal hematopoietic spleen colonies was observed. (3) Host immune responses, including cellular and humoral immunity and interjeron production and action, were not inhibited. Thus, although the effect of slightly decreased weight and intake could not be unequivocally established, the findings were most compatible with a selective inhibition of RL V splenomegaly by Sv.