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Inheritance of susceptibility to friend mouse leukemia virus. XI. Genetic control of late splenomegaly

✍ Scribed by Takeshi Odaka

Publisher: John Wiley and Sons
Year: 1973
Tongue: French
Weight: 326 KB
Volume: 12
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910120113

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✦ Synopsis

Abstract

Genetic control of splenomegaly which occurs at a late stage of Friend leukemia virus infection was studied in hybrid mice between DDD‐Fv^r^ and C57BL/6. It was demonstrated that this late splenomegaly was mainly controlled by a single autosomal locus with the dominant allele for resistance. This locus may be idential with or genetically linked with the locus which controls the level of virus multiplication at an early stage of infection. Considered together with previous findings, splenomegaly induced by Friend leukemia virus in mice is classified into two types, early and late, both being controlled by two separate gene loci.

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