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Inheritance of susceptibility to friend mouse leukemia virus. XII. Effects of the Fv-1 locus

✍ Scribed by Takeshi Odaka

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
429 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The genetic control of susceptibility to the Friend leukemia virus (FLV) complex was studied under conditions which excluded the effect of the Fv locus. From hybrids between two mouse lines which have the same Fv genotype, but differ from each other in response to FLV infection, partially inbred lines were established by selecting for high or low ability to support multiplication of the N‐tropic FLV complex. The results indicated that the Fv‐1 locus controls multiplication of the FLV complex and of the lymphatic leukemia virus (a viral component of FLV complex) and also the development of late splenomegaly. Gene interaction between Fv and Fv‐1 in determining the susceptibility to FLV complex was discussed.

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