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Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A

✍ Scribed by Qunwei Zhang; Konstantin Salnikow; Thomas Kluz; Lung Chi Chen; Wei Cheng Su; Max Costa


Book ID
114087166
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
226 KB
Volume
192
Category
Article
ISSN
0041-008X

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Histone deacetylase inhibitor trichostat
✍ Lina Pan; Jun Lu; Xiuli Wang; Liping Han; Yu Zhang; Songyan Han; Baiqu Huang πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 931 KB

## Abstract ## BACKGROUND. The tumor suppressor gene PTEN is a major negative regulator of the PI3K/Akt cellular survival pathway. Overexpression of PTEN by adenoviral transfection increases doxorubicin‐induced apoptosis. Whereas doxorubicin‐induced apoptosis can be potentiated by the histone deac