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Cell Growth Inhibition and Gene Expression Induced by the Histone Deacetylase Inhibitor, Trichostatin A, on Human Hepatoma Cells

โœ Scribed by Chiba, Tetsuhiro; Yokosuka, Osamu; Fukai, Kenichi; Kojima, Hiroshige; Tada, Motohisa; Arai, Makoto; Imazeki, Fumio; Saisho, Hiromitsu


Book ID
120515498
Publisher
S. Karger AG
Year
2004
Tongue
English
Weight
228 KB
Volume
66
Category
Article
ISSN
0030-2414

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Histone deacetylase inhibitor trichostat
โœ Yo-ichi Yamashita; Mitsuo Shimada; Norifumi Harimoto; Tatsuya Rikimaru; Ken Shir ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 212 KB ๐Ÿ‘ 1 views

## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec