Cytotoxicity and gene expression induced by histone deacetylase inhibitor, trichostatin A, on human hepatoma cells
β Scribed by Tetsuhiro Chiba; Osamu Yokosuka; Kenichi Fukai; Hiroshige Kiojima; Fumio Imazeki; Hiromitsu Saisho
- Book ID
- 119427468
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 188 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec
## Abstract ## BACKGROUND. The tumor suppressor gene PTEN is a major negative regulator of the PI3K/Akt cellular survival pathway. Overexpression of PTEN by adenoviral transfection increases doxorubicinβinduced apoptosis. Whereas doxorubicinβinduced apoptosis can be potentiated by the histone deac