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Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA)

โœ Scribed by Myoung Sook Kim; Jin Hyen Baek; Devulapalli Chakravarty; David Sidransky; France Carrier


Book ID
118506096
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
474 KB
Volume
306
Category
Article
ISSN
0014-4827

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Histone deacetylase inhibitor trichostat
โœ Lina Pan; Jun Lu; Xiuli Wang; Liping Han; Yu Zhang; Songyan Han; Baiqu Huang ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 931 KB

## Abstract ## BACKGROUND. The tumor suppressor gene PTEN is a major negative regulator of the PI3K/Akt cellular survival pathway. Overexpression of PTEN by adenoviral transfection increases doxorubicinโ€induced apoptosis. Whereas doxorubicinโ€induced apoptosis can be potentiated by the histone deac