Influence of food on the disposition of the monoamine oxidase-A inhibitor brofaromine in healthy volunteers

✍ Scribed by Dr P. H. Degen; J. M. Cardot; C. Czendlik; W. Dieterle

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 371 KB
• Volume: 14
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510140304

✦ Synopsis

ty of brolxomine hyr!rocfiioride was investigated t healthy male volunteers were g i x n Tingle peroral r 'hy'rochloride after overnight fasting or a fpt-a:d proteiniich breakfast Mean ( : b SL)) areas under the plasma concentration-time curves (AUC) were 9 -5 6 (2*j5)prm11 h when g i e n to he fasted volunteers and 11.82

(3 73) pmol1-%I (r! -J C r i 3 ) whcn given after a substantial breakfast. Mean (k SD) maximum p1asrr.a conceritrations (Cmax) "vere 0.71 (0.13) pmol1-' when given to the fasted volunteers and 0 85 (0.22) pmol1-' (p>0*05) when given after breakfast. Thus, both the average AUC and C,,, were increased by approximately 20 per cent when brofaromine hydrochloride was given with food. The times when C,,, was reached (tma,.) as well as the elimination half-lives were not influenced by concomitant intake of food. The toierablfity was the same whether brofaromine was given before or after food 11. healthy volunteers The slight effect of food on the bioavailability of brofaromine should be of little therapeutic consequence because of the observed wide inter-subject variability of the plasma levels.