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EFFECTS OF FOOD, ANTACID, AND DOSAGE FORM ON THE PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF SERTINDOLE IN HEALTHY VOLUNTEERS

โœ Scribed by SHEKMAN L. WONG; PAUL LINNEN; RANDALL MACK; G. RICHARD GRANNEMAN

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
125 KB
Volume
18
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The pharmacokinetic disposition and relative bioavailability of sertindole administered as a tablet dosage form under fasting conditions, in the presence of food, in the presence of antacid, and as solution was studied in a four-way crossover in young healthy male volunteers. Overall, tablet dosing after a meal or Maalox had no eect on t 1/2 or AUC values when compared to fasting conditions, but increased the t max and decreased the C max values slightly. The mean relative bioavailabilities of sertindole administered as tablets after fasting, with food, and with Maalox are 99, 104, and 98%, respectively, compared to sertindole solution. Therefore, sertindole can be administered with and without food and without regard to coadministration of antacids. &1997 by John Wiley & Sons, Ltd.

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