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The influence of food on the disposition of the antiepileptic rufinamide in healthy volunteers

โœ Scribed by J.-M. Cardot; J.-B. Lecaillon; C. Czendlik; J. Godbillon

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
115 KB
Volume
19
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The effect of food on the pharmacokinetics of the antiepileptic rufinamide was investigated in healthy volunteers. Twelve subjects were treated with single pre-oral doses of 600 mg of rufinamide after overnight fasting or a fat and protein rich breakfast. Mean (+/- S.D.) areas under the plasma concentration-time curves (AUCs) of the unchanged compound were 57.2 (16) micrograms mL-1 h when given to the fasted volunteers and 81.7 (22.2) micrograms mL-1 h (p = 0.0001) when given after the breakfast. The average AUC was increased by 44% when rufinamide was given with food and the maximum concentration (Cmax) by about 100%. The time at which Cmax was reached (tmax) was shorter (8 h in fasted conditions and 6 h in fed after breakfast); the terminal half-life was not influenced by concomitant intake of food.

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