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The absence of a pharmacokinetic interaction between aspirin and the angiotensin-converting enzyme inhibitor benazepril in healthy volunteers

✍ Scribed by A. Sioufi; F. Pommier; N. Gauducheau; J. Godbillon; L. Choi; V. John

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
491 KB
Volume
15
Category
Article
ISSN
0142-2782

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✦ Synopsis

Potential effects of the coadministration of single doses of aspirin (325mg) and of benazepril hydrochloride (20 mg) on the pharmacokinetics and the metabolism of these two drugs were evaluated in 12 healthy subjects. Plasma concentration profiles of benazepril, its active metabolite benazeprilat, and total salicylic acid were determined together with urinary excretion of benazeprilat, salicylic acid, salicyluric acid, and salicylate glucuronides. Almost superimposable plasma profiies of benazepril, benazeprilat, and total salicylic acid were achieved with the drugs given alone and concomitantly. The coadministration of benazepril hydrochloride and aspirin did not modify the pharmacokinetics or the metabolism of the two drugs.

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