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Influence of debrisoquin phenotype on the inducibility of propranolol metabolism

✍ Scribed by Shaheen, Omar; Biollaz, Jerome; Koshakji, Richard P; Wilkinson, Grant R; Wood, Alastair J J

Book ID
109844664
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
390 KB
Volume
45
Category
Article
ISSN
0009-9236

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Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine