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The debrisoquin hydroxylation phenotype does not predict the metabolism of phenytoin

✍ Scribed by Steiner, E; Alván, G; Garle, M; Maguire, J H; Lind, M; Nilson, S-O; Tomson, T; McClanahan, J S; Sjöqvist, F


Book ID
109844149
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
548 KB
Volume
42
Category
Article
ISSN
0009-9236

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Influence of debrisoquine hydroxylation
✍ P. Lledó; S. M. L. Abrams; A. Johnston; M. Patel; R. M. Pearson; P. Turner 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 521 KB

Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine