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Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype

✍ Scribed by Spina, Edoardo; Steiner, Eugen; Ericsson, Örjan; Sjöqvist, Folke

Book ID
109844240
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
330 KB
Volume
41
Category
Article
ISSN
0009-9236

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Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine