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Diurnal effects on debrisoquine hydroxylation phenotyping

✍ Scribed by E. J. D. Lee

Book ID
104810735
Publisher
Springer
Year
1988
Tongue
English
Weight
143 KB
Volume
35
Category
Article
ISSN
0031-6970

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πŸ“œ SIMILAR VOLUMES

Influence of debrisoquine hydroxylation
Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine
✍ P. LledΓ³; S. M. L. Abrams; A. Johnston; M. Patel; R. M. Pearson; P. Turner πŸ“‚ Article πŸ“… 1993 πŸ› Springer 🌐 English βš– 521 KB

Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine