Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine
β¦ LIBER β¦
The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers
β Scribed by P. A. Philip; C. A. James; H. J. Rogers
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 299 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0031-6970
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## Abstract Metoprolol is a Ξ²βblocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol