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The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide

✍ Scribed by Mikus, Gerd; Gross, Annette S; Beckmann, Jürgen; Hertrampf, Rita; Gundert-Remy, Ursula; Eichelbaum, Michel


Book ID
109844686
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
456 KB
Volume
45
Category
Article
ISSN
0009-9236

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Influence of debrisoquine hydroxylation
✍ P. Lledó; S. M. L. Abrams; A. Johnston; M. Patel; R. M. Pearson; P. Turner 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 521 KB

Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine