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Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes

โœ Scribed by Ho, P C; Abbott, F S; Zanger, U M; Chang, T K H

Book ID
110075288
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
132 KB
Volume
3
Category
Article
ISSN
1470-269X

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โœ P. Bonnabry; T. Leemann; P. Dayer ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer ๐ŸŒ English โš– 447 KB

## Objective: The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. the reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolis