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Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

✍ Scribed by Li ZHANG; Min-ji WEI; Cai-yun ZHAO; Hui-min QI

Book ID: 111357217
Publisher: Nature Publishing Group
Year: 2008
Tongue: Chinese
Weight: 548 KB
Volume: 29
Category: Article
ISSN: 1671-4083
DOI: 10.1111/j.1745-7254.2008.00908.x

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## Objective: The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. the reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolis