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Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

✍ Scribed by Hiroshi Yamazaki; Kiyoshi Inoue; Masafumi Hashimoto; Tsutomu Shimada

Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
123 KB
Volume
73
Category
Article
ISSN
0340-5761

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## Objective: The nature of the enzyme(s) catalysing the biotransformation of lornoxicam to one of its major metabolites, 5'-hydroxy-lornoxicam, has been investigated in human liver microsomes. the reaction kinetics were characterised, the affinity of lornoxicam for three major human drug metabolis