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Infection of a human retinal pigment epithelial cell line with human herpesvirus 6 variant A

✍ Scribed by Arao, Yujiro; Soushi, Sumi; Sato, Yuko; Moriishi, Eiko; Ando, Yasutaka; Yamada, Masao; Padilla, Jorge; Uno, Fumio; Nii, Shiro; Kurata, Takeshi

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 525 KB
Volume: 53
Category: Article
ISSN: 0146-6615
DOI: 10.1002/(sici)1096-9071(199710)53:2<105::aid-jmv1>3.0.co;2-d

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✦ Synopsis

A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral glycoprotein B was detected by immunofluorescence assay. These results indicate that K-1034 cells are susceptible to HHV-6A and suggest that HHV-6A has an ability to directly destroy epithelial cells.

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