Post-mortem diagnosis of encephalitis in a 75-year-old man associated with human herpesvirus-6 variant A
✍ Scribed by Marinella Portolani; Maria Grazia Tamassia; William Gennari; Monica Pecorari; Francesca Beretti; Milena Alù; Antonio Maiorana; Mario Migaldi
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 168 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
An HHV-6 variant A infection is described in a 75 year-old man in association with meningoencephalitis identified at autopsy. The patient presented with fever and anorexia, then he developed altered consciousness, motor weakness, progressive lethargy, and coma, and died 21 days after hospital admission. Histopathological examination showed perivascular lymphocytic infiltrates in the central nervous system (CNS). Serum and cerebral spinal fluid (CSF) samples drawn from the patient were tested for viruses by a nested polymerase chain reaction (nPCR).