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Induction of sister-chromatid exchanges by N-nitrosocimetidine in cultured human lymphocytes and their inhibition by several chemical compounds

✍ Scribed by K. Inoue; T. Shibata; H. Kosaka; T. Kimura; M. Uozumi; Y. Oda; T. Abe

Book ID
113250721
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
80 KB
Volume
130
Category
Article
ISSN
0165-1161

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Induction of sister chromatid exchanges
Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures
✍ Ünal Egeli 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB 👁 2 views

This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m