Induction of micronuclei and sister chromatid exchanges by polycyclic and N-heterocyclic aromatic hydrocarbons in cultured human lymphocytes
✍ Scribed by D. Warshawssky; G. K. Livingston; M. Fonouni-Fard; K. Ladow
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 958 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Abstract The ability of three ultimate metabolites of benzo(__a__)‐pyrene and of 7‐bromomethylbenz(__a__)anthracene to induce 8‐azaguanine mutants, sister‐chromatid exchanges and chromosome aberrations has been investigated. 7β,8α‐dihydroxy‐9α,10α‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene was
The genetic polymorphisms of glutathione S-trans-(50 mM) and 1.4 (150 mM) times greater among ferases (GSTs), which are involved in the metabolic the GSTT1 null individuals (4.83 at 50 mM, 18.98 inactivation of various toxicants, have been sug-at 150 mM) compared with the GSTT1 positive indigested t