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Induction of “sister-chromatid exchange” by city smog extracts and their fractions in cultured human lymphocytes

✍ Scribed by C.-C. Schürer; N. Manojlovic; N.H. Seemayer

Book ID
113250043
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
140 KB
Volume
85
Category
Article
ISSN
0165-1161

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Induction of sister chromatid exchanges
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m