Induction of sister chromatid exchanges and inhibition of cellular proliferation in vitro. I. caffeine
β Scribed by Guglielmi, Gwen E. ;Vogt, Thomas F. ;Tice, Raymond R.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1982
- Weight
- 616 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0192-2521
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Abstract The induction of chromosomal aberrations and sister chromatid exchange __in vivo__ in mouse spleen and bone marrow as well as __in vitro__ in cultured mouse spleen cells by the insecticide βCypermethrinβ (__cistrans__ 1:1) was investigated. The percentage of chromsomal aberrations in t