Induction of sister chromatid exchanges by benzidine in rat and human hepatoma cell lines and inhibition by indomethacin
โ Scribed by Mary Kay Grady; David Jacobson-Kram; Kerry L. Dearfield; Jerry R. Williams
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 473 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0742-2091
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Abstract The frequency of sister chromatid exchange (SCE) in WIโ38 cells was estimated by the 5โbromodeoxyuridine (BrdUrd)โdye technique after one hour's exposure to cyclophosphamide (CY), NโmethylโNโฒโnitroโNโnitrosoguanidine (MNNG), 4โnitroquinolineโ1โoxide (4NQO), and maleic hydrazide (MH) wit