Induction of micronuclei by 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in Chinese hamster V79MZh1A1 cells
✍ Scribed by Timea Farkašová; Alena Gábelová; Darina Slameňová
- Book ID
- 117766677
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 378 KB
- Volume
- 491
- Category
- Article
- ISSN
- 1383-5718
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## Abstract The cytochrome P4501A subfamily (CYP1A) is involved in the metabolic activation of __7H__‐dibenzo[__c,g__]carbazole (DBC) and its tissue‐ and organ‐specific derivatives, __N__‐methyldibenzo[__c,g__]carbazole (MeDBC)and 5,9‐dimethyldibenzo[__c,g__]carbazole (diMeDBC). In this study, we h
The nuclease P1 modification of the 32 P-postlabeling DNA-adducts in the embryo cells, which suggests that technique was used to study the biological activity the enzymatic composition of the target tissue probaof 7H-dibenzo[c,g]carbazole (DBC) and some of its bly is the determining factor in the or
Parenchymal (PC) and nonparenchymal (NPC) liver which is exclusively hepatocarcinogenic, were anacells have different tissue-specific, procarcinogen lyzed in parallel. Both PC and NPC generated the activation enzymes. NPC appear to be protected ultimate metabolites of DBC, but NPC were substanagains