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Induction of Autoimmunity A Role for the Idiotypic Network

✍ Scribed by YEHUDA SHOENFELD; JACOB GEORGE

Book ID
111393319
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
419 KB
Volume
815
Category
Article
ISSN
0890-6564

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Systemic lupus erythematosus (SLE) has been induced in C3H.SW mice by their immunization with a human monoclonal anti-DNA antibody that bears a common idiotype-16/6 Id. Following immunization, high levels of murine anti-l6/6 and anti-anti-l6/6 antibodies were detected in the sera of the immunized mi