Mechanisms of autoimmunity: a role for cross-reactive idiotypes
โ Scribed by Anne Cooke; P.M Lydyard; I.M Roitt
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 591 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0167-5699
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## Abstract Previous investigations have demonstrated the feasibility of suppressing the production of an idiotype, associated with antiโpโazophenylarsonate antibodies in A/J mice, by pretreatment of adult mice with antiโidiotypic antiserum. The present study indicates that immunological memory, wi
## Abstract The antiโpโazophenylarsonate antibodies of A/J mice express a major intrastrain crossโreactive idiotype (CRI~A~). Using a sensitive radioimmunoassay we were unable to detect significant quantities of molecules bearing CRI~A~ in nonimmune A/J sera. The upper limit is 140 ng/ml. Possible
Rheumatoid factors (RFs) are present in a wide spectrum of diseases, but the diversity of these antibodies may vary greatly according to the underlying disease process. To analyze the diversity of these molecules, we have recently developed in the Scripps laboratory three cross-reactive idiotypic re