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Induction and reduction of sister chromatid exchange by CCNU in human lymphocytes in vitro

✍ Scribed by Wendell H. McKenzie; Bo Lambert

Book ID
119102671
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
625 KB
Volume
9
Category
Article
ISSN
0165-4608

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Induction of sister chromatid exchanges
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m