✦ LIBER ✦

Inducible control of gene expression: prospects for gene therapy

✍ Scribed by iane M Harvey; C Thomas Caskey

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 793 KB
Volume: 2
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(98)80128-2

No coin nor oath required. For personal study only.

✦ Synopsis

A number of drug-related gene expression systems are available for controlling target gene transcription through the use of small-molecule inducing compounds. While the utility of such systems has been demonstrated in vitro and in transgenic mice, recent improvements are likely to make these systems more amenable for use in a therapeutic context, such as gene therapy. These improvements include further optimization of the antiprogestin-regulated gene switch, rendering it more sensitive to RU486, and the synthesis of nonimmunosuppressive rapamycin analogs for use in dimerization-based strategies of gene regulation.

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