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Gene-specific mechanisms of p53 transcriptional control and prospects for cancer therapy

✍ Scribed by Lois Resnick-Silverman; James J. Manfredi

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
186 KB
Volume
99
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

The regulation of gene‐specific activation is critical to the tumor suppressor function by p53. p53 is a well‐characterized transcription factor that responds to DNA damage and other genotoxic stresses by the activation of downstream targets that are involved with repair, differentiation, senescence, growth arrest, and apoptosis. Sequence‐specific binding to DNA, conformation, post‐translational modifications, cofactor binding, stability, and subcellular localization all influence the performance of p53. The purpose of this review is to define features that play a key role in gene‐specific activation and to show that these are often incapacitated in cancer cells. Using such knowledge to design selective strategies for the restoration of p53 wild‐type function in cancer cells represents a promising cancer therapy. J. Cell. Biochem. 99: 679–689, 2006. © 2006 Wiley‐Liss, Inc.

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