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Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

✍ Scribed by Jan-Sören Padberg, Matijs Van Meurs…


Book ID
120717538
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
254 KB
Volume
4
Category
Article
ISSN
2040-7378

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c