✦ LIBER ✦

Increased transcriptional activity of the CYP3A4*1B promoter variant

✍ Scribed by B. Amirimani; B. Ning; A.C. Deitz; B.L. Weber; F.F. Kadlubar; T.R. Rebbeck

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 163 KB
Volume: 42
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.10199

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Promoter activity and regulation of the

Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia

✍ Vladimir Mastyugin; Alexandre Mezentsev; Wen-Xiang Zhang; Silvia Ashkar; Michael 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 846 KB

## Abstract Hypoxic injury to the ocular surface provokes an inflammatory response that is mediated, in part, by corneal epithelial‐derived 12‐hydroxyeicosanoids. Recent studies indicate that a cytochrome P450 (CYP) monooxygenase, identified as CYP4B1, is involved in the production of these eicosan

A Highly Active Single-Mutation Variant

A Highly Active Single-Mutation Variant of P450BM3 (CYP102A1)

✍ Christopher J. C. Whitehouse; Stephen G. Bell; Wen Yang; Jake A. Yorke; Christop 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB

Functional evaluation of novel single nu

Functional evaluation of novel single nucleotide polymorphisms and haplotypes in the promoter regions of CYP1B1 and CYP1A1 genes

✍ Weiguo Han; Brian T. Pentecost; Simon D. Spivack 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB

Interindividual variation in the expression of the carcinogen- and estrogen-metabolizing enzymes cytochrome P4501B1 and 1A1 (CYP1B1 and CYP1A1) has been detected in human lung. To search for polymorphisms with functional consequences for CYP1B1 and CYP1A1 gene expression, we examined 1.5 kb of the p

Glucocorticoid can reduce the transcript

Glucocorticoid can reduce the transcriptional activation of HIV-1 promoter through the reduction of active NF-κB

✍ Shun-ichi Kurata; Naoki Yamamoto 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

It is well documented that glucocorticoid (GC) can induce the transcription of the IB␣ gene in several cell lines. GC treatment then increases IB␣ protein levels and markedly reduces the amount of active NF-B. NF-B is a strong activator of HIV-1 promoter, but the mechanism by which GC influence the

A New Variant for the Synthesis of 1H-Py

A New Variant for the Synthesis of 1H-Pyrazolo[3,4-b]pyridines

✍ Dipl.-Chem. Jochen Häufel; Doz. Dr. Eberhard Breitmaier 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 2 views

m. p.=248-250GC (dec.; from methanol); [.ID= -129.' (DMSO, c = 1.00); 'H-NMR (D6-DMSO); t=4.13 and 4.18 (s, I-H+l'-H and s, 2 2-benzyl-H, or vice versa); MS: 520 (M+)]. The amino ketone ( 8 ) is probably first formed, being later aromatized by dimerization and air oxidation to yield ( 9 ) . The firs

Histone H4 proximal promoter mediates a

Histone H4 proximal promoter mediates a complex transcriptional response during differentiation of 3T3L1 adipocytes

✍ Dr. Anna L. Ramsey-Ewing; Rita Bortell; Gary S. Stein; Janet L. Stein 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 901 KB

We have investigated the promoter element(s) required by the cell cycle regulated FO108 human histone \(\mathrm{H} 4\) gene for control of gene expression during adipocyte proliferation and differentiation. Stable 3T3L1 cell lines were established that express fusion genes in which the histone \(\ma