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Glucocorticoid can reduce the transcriptional activation of HIV-1 promoter through the reduction of active NF-κB

✍ Scribed by Shun-ichi Kurata; Naoki Yamamoto

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
188 KB
Volume
76
Category
Article
ISSN
0730-2312

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✦ Synopsis

It is well documented that glucocorticoid (GC) can induce the transcription of the IB␣ gene in several cell lines. GC treatment then increases IB␣ protein levels and markedly reduces the amount of active NF-B. NF-B is a strong activator of HIV-1 promoter, but the mechanism by which GC influence the HIV-1 activities is not well documented. In the present study, MOLT4 and Jurkat cells were transfected with HIV-1-LTR-CAT DNA and treated with 0.2 mM H 2 O 2 or 10 ng/ml of TPA. CAT activities of the transformed MOLT4 and Jurkat cells were greatly enhanced by these treatments, but the CAT activities were markedly reduced when cells were pretreated with GC. This reduction in activity correlated well with the reduction in active NF-B and the accumulation of IB␣. These findings suggest that GC can reduce the transcription of HIV-1 promoter through the reduction of active NF-B.

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