𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transcriptional activation of survivin through the NF-κB pathway by human T-cell leukemia virus type I tax

✍ Scribed by Hirochika Kawakami; Mariko Tomita; Takehiro Matsuda; Takao Ohta; Yuetsu Tanaka; Masahiro Fujii; Masahiko Hatano; Takeshi Tokuhisa; Naoki Mori

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
273 KB
Volume
115
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Survivin, a unique member of the inhibitor of apoptosis protein family, is overexpressed in many cancers and considered to play an important role in oncogenesis. We previously reported the survivin expression profile in ATL, a CD4‐positive T‐cell malignancy caused by HTLV‐I. HTLV‐I Tax is thought to play an important role in immortalization of T cells. We have shown also that the expression of Tax protected the mouse T‐cell line CTLL‐2 against apoptosis induced by deprivation of IL‐2 and converted its growth from being IL‐2 dependent to being IL‐2 independent through the NF‐κB pathway. In our study, we demonstrate that constitutive expression of survivin was associated with resistance to apoptosis after IL‐2 deprivation in Tax‐expressing CTLL‐2 cells. Transient transfection assays showed that survivin promoter was transactivated by Tax, via the activation of NF‐κB. Pharmacological NF‐κB inhibition resulted in suppression of survivin expression and caused apoptosis of Tax‐expressing CTLL‐2 cells. Our findings suggest that activated NF‐κB signaling contributes directly to malignant progression of ATL by preventing apoptosis, acting through the prosurvival protein survivin. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Retracted: Curcumin (diferuloylmethane)
Retracted: Curcumin (diferuloylmethane) inhibits constitutive active NF-κB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
✍ Mariko Tomita; Hirochika Kawakami; Jun-nosuke Uchihara; Taeko Okudaira; Masato M 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 378 KB

## Abstract Retraction: The following article has been retracted through agreement between the first author and several coauthors, the journal Editor‐in‐Chief, Peter Lichter, and John Wiley & Sons, Ltd.: Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y,

Differential patterns of human cytomegal
Differential patterns of human cytomegalovirus gene expression in various T-cell lines carrying human T-cell leukemia-lymphoma virus type I: Role of tax-activated cellular transcription factors
✍ Zoltán Beck; Attila Bácsi; Xiangdong Liu; Peter Ebbesen; István Andirkó; Eszter 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB

## Abstract Replication of human cytomegalovirus (HCMV) was investigated in various T‐cell lines expressing the __tax__ gene product of human T‐cell leukemia‐lymphoma virus type I (HTLV‐I). Differential patterns of HCMV replication were found in HTLV‐I‐carrying cell lines. HCMV gene expression was

Activation of cyclin D1 and D2 promoters
Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2–independent growth of T cells
✍ Naoki Mori; Masahiro Fujii; Michael Hinz; Katsushi Nakayama; Yasuaki Yamada; Shu 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 444 KB

## Abstract Our aim was to examine the involvement of G~1~ cell‐cycle regulators in cell growth dysregulation induced by HTLV‐I. Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV‐I–infected T‐cell lines, which were at least in part mediated by the