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A Highly Active Single-Mutation Variant of P450BM3 (CYP102A1)

✍ Scribed by Christopher J. C. Whitehouse; Stephen G. Bell; Wen Yang; Jake A. Yorke; Christopher F. Blanford; Anthony J. F. Strong; Edward J. Morse; Mark Bartlam; Zihe Rao; Luet-Lok Wong


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
275 KB
Volume
10
Category
Article
ISSN
1439-4227

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πŸ“œ SIMILAR VOLUMES


Desaturation of Alkylbenzenes by Cytochr
✍ Christopherβ€…J.β€…C. Whitehouse; Stephenβ€…G. Bell; Luet-Lok Wong πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 197 KB

Figure 1. Product distributions in the oxidation of alkylbenzenes by wildtype CYP102A1 (WT) and variant KT5 (F87A7A330P/E377A/D425N).

Dearomatisation of o-Xylene by P450BM3 (
✍ Dr. Christopher J. C. Whitehouse; Dr. Nicholas H. Rees; Dr. Stephen G. Bell; Dr. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 467 KB

## Abstract The oxidation of __o__‐xylene by P450~BM3~ from __Bacillus megaterium__ yields, in addition to the products formed by microsomal P450s, two metabolites containing an NIH‐shifted methyl group, one of which lacks the aromatic character of the substrate. The failure of the epoxide precurso