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Increased Expression of c-Kit in Mucosal Melanoma

✍ Scribed by Calvin Wei; Kepal Patel; Beverly Wang

Book ID: 116815688
Publisher: SAGE Publications
Year: 2010
Tongue: English
Weight: 48 KB
Volume: 143
Category: Article
ISSN: 0194-5998
DOI: 10.1016/j.otohns.2010.06.073

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## Abstract Recent studies showed __KIT__ gene aberrations in a substantial number of melanomas on acral skin and mucosa, suggesting the therapeutic benefit of tyrosine kinase inhibitors, such as imatinib. We therefore examined the expression and mutations of __KIT__ in 4 primary and 24 metastatic